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The 2024 Yang paper in Journal for ImmunoTherapy of Cancer documented NNMT in cancer-associated fibroblasts driving tumour progression (PMID 39067875)

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The honest answer is that we do not fully know, and the available evidence cuts in more than one direction

The preponderance of evidence suggests that recent hippocampal learning is consolidated during sleep through the reinforcement of hippocampal replay (lafsdttir et al., 2018)